Background: From a pharmacokinetic standpoint, middle ear effusion(MEE) acts as a sequestered compartment since diffusion of antibiotics from serum and to this compartment is limited. The effectiveness of an antibiotic to eradicate infection
within
an
anatomic compartment is related to both its ability to penetrate and the susceptibility of the causative pathogen. Objective: The goal of this study was to determine the steady state plasma and MEE concentrations of cefprozil in pediatric
chronic
otitis media with effusion(COME). Materials and Methods: Twenty-five children with COME were enrolled, and MEE was collected using a ventilation tube insertion after 0.5, 2, 3, 5, and 6 hours of single oral administration of 15 mg Cefprozil/kg
body
weight. Blood samples were also collected as soon as the MEE was collected, and analyzed in order to measure the concentration of Cefprozil using the validated high performance liquid chromatography(HPLC) method. Results: The mean concentrations
of
cefprozil in MEE ranged from 0.4 to 4.4 ug/ml. The penetration of cefprozil into the MEE was rapid and effectively. Cefprozil in the MEE was maintained at a greater level than MIC90 in Streptococcus pneumoniae for at least 6 hours after
administration
of 15mg/kg
Conclusion: Cefprozil penetrates well into MEE in patients with pediatric
COME.
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